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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Biomaterials. 2012 Feb 15;33(13):3548–3559. doi: 10.1016/j.biomaterials.2012.01.055

Figure 5. Influence of adhesion on cancerous MEC phenotypes.

Figure 5

10A.ErbB2 and 231 cells in PEG hydrogels both produced a variety of phenotypes that depended on adhesion identity and concentration. Sizes of 10A.ErbB2 structures were measured and normalized to blank hydrogels for a given experiment (A), with mean +/− s.d. values taken from three independent experiments. Conditions with different letters were significantly different (p<0.05). Confocal images for structures were classified as described in Fig. 3 for cell organizations and laminin V distributions. 10A.ErbB2 cell organization showed differences between adhesion conditions (p=2e-15) (B) with associations revealed by correspondence analysis (C). Laminin V distribution within 10A.ErbB2 structures varied with adhesion condition (p=8e-5) (D) with associations revealed by correspondence analysis (E). Sizes of 231 structures were measured and normalized to blank hydrogels for a given experiment (F). 231 cell organization had differences between adhesion conditions (p<2e-16) (G) with associations revealed by correspondence analysis (H).