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. 2012 Feb 28;3:28. doi: 10.3389/fphar.2012.00028

Figure 4.

Figure 4

Peptide Ac2-26 induced PMN migration relies primarily on the ERK signaling pathway. Neutrophils were pre-incubated for 15 min at 37°C with either (A) PD98059 (ERK inhibitor; 3–30 μM), (B) SB203580 (p38 inhibitor; 3–30 μM), or (C) SP600125 (JNK inhibitor; 3–30 μM) prior to loading on to a 96 well ChemoTx™ plate in the presence of PBS or peptide Ac2-26 (3–30 μM). Chemotaxis was evaluated after a 90-min incubation at 37°C and 5% CO2. Results are ±SEM from three distinct cell preparations [*P < 0.05, **P < 0.01 vs. stimulus alone (dose 0 group)].