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Bioactive compounds isolated from didemnid ascidians. The natural products shown here have unique mechanisms of action against diverse targets, and some are potent to ~100 pM against cancer-relevant cell lines. (Note: trunkamide has been reported to be both the L- and D-Phe isomer from the natural source. We have found that the pathway naturally produces the L-Phe isomer, which slowly isomerizes to the D-form.)
