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Pretreatment with NAC (i.m.) 30 min or 3 hr prior to i.v. administration of saline did not significantly alter rates of responding under a fixed-interval avoidance schedule (A, C). Pretreatment with NAC (i.m.) 30 min or 3 h prior to cocaine administration did not significantly alter cocaine-induced increases in rates of responding (B, D). Abscissae: time in minutes. Ordinates: rates of responding expressed as a percent of baseline control rates.
