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Administration of NAC did not significantly alter rates of responding maintained by a second-order schedule of cocaine self-administration. Each dose of NAC was administered 30 min or 3 hr prior to the start of the self-administration session for three consecutive days. The solid line at 100% represents baseline responding during cocaine self-administration. Abscissae: dose of NAC pretreatment. Ordinates: rates of responding expressed as a percent of baseline control rates.
