Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Brain Behav Immun. 2011 Nov 12;26(3):371–382. doi: 10.1016/j.bbi.2011.11.002

Figure 4.

Figure 4

Antibiotic reduction of the intestinal microbiota abrogated the SDR stressor-induced increase in bacterial killing and peroxynitrite production. Fig. 4A–D: Exposure to the SDR stressor increased spleen mass, the number of splenic monocytes/macrophages, the number of splenic neutrophils, and the number of splenic lymphocytes in both vehicle- and antibiotic-treated mice (*p<0.05 vs. HCC Control). Fig 4E: Exposing vehicle-treated mice to the SDR stressor significantly increased phagocytosis (*p<0.05 vs. HCC Control at 20 min) and bacterial killing (*p<0.05 vs. HCC Control and 90 min). However, SDR stressor exposure failed to enhance bacterial killing by macrophages from antibiotic-treated mice. Fig 4F: Splenic macrophages from vehicle-treated mice exposed to the SDR stressor produced significantly higher levels of peroxynitrite (*p<0.05 vs. all other groups at 60, 75, and 90 min of stimulation). Values are means ± SE [n=8(HCC Control Vehicle), n=8(SDR Stressor Vehicle), n=8(HCC Control Antibiotics), n=8(SDR Stressor Antibiotics)].