Skip to main content
. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Hippocampus. 2011 Nov 10;22(6):1438–1450. doi: 10.1002/hipo.20984

Fig. 3.

Fig. 3

CCK enhances NMDA receptor currents via activation of CCK-2 receptors. A, Pretreatment of cells with and continuous bath application of LY225910 (5 μM) blocked CCK-induced enhancement of NMDA currents. Left, NMDA currents recorded before (upper) and after (lower) the application of CCK in the presence of LY225910. Right, Pooled data from 8 cells. B, Application of CCK failed to facilitate NMDA currents in granule cells (n=13 cells) isolated from 4 CCK-2 KO mice whereas application of CCK still significantly increased NMDA currents in granule cells (n=9 cells) isolated from 3 WT mice.