Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Eur J Med Chem. 2012 Jan 12;49C:191–199. doi: 10.1016/j.ejmech.2012.01.010

Table 2.

Anti-HCV effects of STLC derivatives in cell based reporter assay.

Compound BHK-NS5B-FRLuca
 Huh7/Rep-Feolbb
Viability (%) Inhibition (%) Viability (%) Inhibition (%)
F-3070 100.0 85.4 72.6 89.5
E-3205 30.2 44.4 44.2 88.6
F-3065 100.0 84.3 74.1 91.2
a

BHK-NS5B-FRLuc and

b

Huh7/Rep-Feolb reporter cells were treated with the indicated compounds at 100 μM concentration for 42 h.

Cell viability in the BHK-NS5B-FRLuc reportera was estimated as the relative levels of Firefly luciferase in compound treated cells versus DMSO controls, while mat in the Huh7/Rep-Feo lb cellsb was evaluated by the MTS assay. The inhibitory effect of the compounds on NS5B RdRp activitya and HCV RNA replicationb is presented as percent of DMSO treated controls. Data represents an average of three independent experiments in duplicate.