. Author manuscript; available in PMC: 2013 Sep 1.

Published in final edited form as: Int J Cancer. 2011 Nov 19;131(5):1153–1157. doi: 10.1002/ijc.26484

Table 3.

Informative (Methylated) Genes Selected for Composite Biomarker for Colorectal Cancer and for Colonic Adenoma Detection by the Fixed Cut-Off Approach. The number (and percentage) of samples with methylated gene is shown. Sensitivity (Se) and Specificity (Sp) for the informative genes that differentiated colorectal cancer from controls are listed.

Gene	Informative for CRC	Informative For Adenoma	Controls N=30	Adenoma N=30	Colorectal Cancer N=30
RASSF1A	+	+	14 (47%)	23 (82%)	28 (Se=93%, Sp=53%)
HIC1	+	+	2 (7%)	9 (30%)	19 (Se=63%, Sp=93%)
CYCD2	+	−	19 (63%)	23 (82%)	29 (Se=97%, Sp=37%)
PAX5	+	−	17 (57%)	21 (75%)	26 (Se=87%, Sp=43%)
RB1	+	−	14 (47%)	19 (68%)	27 (Se=90%, Sp=53%)
SRBC	+	−	2 (7%)	3 (11%)	10 (Se=33%, Sp=93%)