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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Inflamm Bowel Dis. 2011 Nov 13;18(7):1303–1314. doi: 10.1002/ibd.21930

Figure 2.

Figure 2

St14 hypomorphic mice are substantially more susceptible to DSS-induced colitis. Wild type C57BL/6J (n=4), St14 hypomorphs (Hypomorph; n=24) and heterozygote control littermates (Control; n=22) were administered DSS in drinking water for 7 days and on day 8, were returned to water only. (A) Body weight of St14 hypomorph and control groups during the course of treatment. # indicate average of data from surviving mice only. (B) Survival. All wild type C57BL/6J and Control mice survived, whereas only 8 St14 hypomorphic mice survived to day 14. p=0.0085, Kaplan Meier Survival analysis. (C) Scores of clinical disease. n=16 per group; *p <0.05, **p <0.005, Mann Whitney U Test. (D) Survival of St14 hypomorph and littermate control mice exposed to continuous DSS in drinking water. n=8 per group.