Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Clin Immunol. 2011 Nov 15;142(3):291–295. doi: 10.1016/j.clim.2011.11.004

Figure 3. pCons reduces TEff suppression by TReg in a p38-independent fashion.

Figure 3

Groups of 7-8 NZB/W mice each were injected daily with the p38 inhibitor SB203580 (p38-inh) or control SB202474 (p38-c) for 14 days. On day 7, mice were tolerized with pCons or given control pNeg. After one week, ex vivo sorted TEff (TE) were CFSE-labeled and cocultured with TReg (TR) in the presence of CD3/CD28 Ab for 3 days before flow cytometry. Representative (A) and cumulative data of TEff suppression by TReg (B-C). *P<0.002 by ANOVA.