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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Dec 9;1819(3-4):313–321. doi: 10.1016/j.bbagrm.2011.11.002

Fig. 1.

Fig. 1

Model of CENP-A containing chromatin throughout the cell cycle in animals. The levels of CENP-A at centromeres change with the cell cycle. Prior to S phase, CENP-A is fully loaded at the centromere, but upon replication, the number of CENP-A molecules present on each daughter strand are reduced to half per centromere copy as no new CENP-A protein is added. During G2, new CENP-A is synthesized and assembles into a soluble complex with its binding partner H4 and its chaperone HJURPScm3, but is not deposited at centromeres until G1. Cells progress through mitosis with half-loaded centromeres. During late anaphase/telophase, HJURPScm3 begins to deposit CENP-A to duplicate CENP-A protein levels.