Table 2.
Ingenuity Pathways Analysis (IPA7.5) Results for 81 alternatively spliced genes
| TOP NETWORKS
| |
|---|---|
| Network | Score |
| Cancer, Cell Death, Hematological Disease | 20 |
| Cancer, Developmental Disorder, Embryonic Development | 23 |
| Neurological Disease, Skeletal and Muscular Disorders, Cellular Compromise | 23 |
| Genetic Disorder, Skeletal and Muscular Disorders, Development Disorders | 28 |
| TOP BIO FUNCTIONS
| ||
|---|---|---|
| Disease and Disorders
| ||
| Name | p-Value | Molecules |
| Cancer | 4.11e-03 – 4.57e-02 | 11 |
| Genetic Disorder | 4.11e-03 – 4.83e-02 | 11 |
| Dermatological Diseases and conditions | 4.11e-03 – 4.43e-02 | 10 |
| Skeletal and Muscular Disorders | 3.44e-04 – 4.83e-02 | 9 |
| Cardiovascular Diseases | 4.11e-03 – 4.43e-02 | 7 |
|
| ||
|
Molecular and Cellular Functions
| ||
| Name | p-Value | Molecules |
|
| ||
| Cellular Compromise | 9.40e-04 – 4.49e-02 | 13 |
| Cell Death | 3.44e-04 – 4.83e-02 | 12 |
| Cell Morphology | 4.97e-05 – 1.63e-02 | 8 |
| Protein Degradation | 9.40e-04 – 4.69e-02 | 4 |
| Carbohydrate Metabolism | 1.46e-03 – 4.04e-02 | 3 |
|
| ||
|
Physiological System Development and Function
| ||
| Name | p-Value | Molecules |
|
| ||
| Embryonic Development | 4.11e-03 – 4.04e-02 | 9 |
| Cardiovascular System Development and Function | 4.11e-03 – 3.64e-02 | 5 |
| Digestive System Development and Function | 4.97e-05 – 4.97e-05 | 2 |
| Connective Tissue Development and Function | 4.11e-03 – 4.11e-03 | 1 |
| TOP CANONICAL PATHWAYS
| ||
|---|---|---|
| Name | p-Value | Ratio |
| Glycosaminoglycan Degradation | 3.6e-04 | 3/72 (0.042) |
| Mitochondrial Dysfunction | 1.99e-03 | 4/172 (0.023) |
| Parkinson’s Signaling | 2.17e-03 | 2/17 (0.118) |
| Docosahexaenoic Acid (DHA) Signaling | 9.03e-03 | 2/45 (0.044) |
| Oxidative Phosphorylation | 1.84e-02 | 3/166 (0.018) |