Table 2.

Final Multivariable Prognostic Model for Six-Month Mortality (PROMPT)

Risk Factor	Total Sample
	ORa	95% CI
Ageb	1.21c	-	-
Age1	1.03	1.00	1.05
Age2	0.93	0.85	1.03
Age 3	1.29	0.99	1.68
Sex
Male	1.54	1.41	1.67
Female	(ref)	-	-
Any cancer
Yes	2.96	2.72	3.21
No	(ref)	-	-
Congestive heart failure
Yes	1.23	1.13	1.35
No	(ref)	-	-
COPD
Yes	1.15	1.04	1.26
No	(ref)	-	-
Smoking status
Former smoker	1.38	1.26	1.52
Current smoker	1.31	1.13	1.52
Never smoked	(ref)	-	-
Proxy status
Proxy respondent	1.71	1.56	1.89
Missing	1.01	0.86	1.17
Person to whom the survey was addressed	(ref)	-	-
Activities of Daily Living (ADL)d	1.21	1.18	1.24
Health-related quality of life (HRQOL)e
General Health Perceptions	0.98	0.97	0.98
Social Functioning	0.99	0.98	0.99
Energy/Fatigue	0.99	0.98	0.99

PROMPT = Patient Reported Outcome Mortality Prediction Tool; OR = odds ratio; 95% CI = 95% confidence interval; COPD = chronic obstructive pulmonary disease.

^aFinal parameter estimates (odds ratios) calculated using entire data sample (n=21,870).

^bAge modeled using Restricted Cubic Spline function with four knots at the 5%, 35%, 65%, and 95% age percentiles given by C(u) = β₁u + θ₁c₁(u) + θ₂c₂(u) where c₁(u) and c₂(u) are cubic terms.

^cOR is for age 75 relative to age 65, for illustrative purposes.

^dOdds per single unit increase in impaired ADL, where higher scores indicate greater functional impairment (ADL score is the total number of activities scored as “unable to do,” range 0–6; 0 indicates able to perform all activities, 6 indicates unable to perform all activities).

^eOdds per single unit increase in standardized SF-36 scale T-score (mean=50, SD=10); higher scores represent greater HRQOL.