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. Author manuscript; available in PMC: 2012 Feb 28.
Published in final edited form as: J Appl Physiol (1985). 2007 Dec 6;104(3):588–600. doi: 10.1152/japplphysiol.01096.2007

Fig. 4.

Fig. 4

Unidirectional shear stress increases expression of eNOS mRNA. A: amount of eNOS mRNA in endothelial cells exposed to no shear stress or to 6 h of shear stress at 15 dyn/cm2. *P < 0.05 vs. static. B: exposure of endothelial cells to shear stress for 6 h increased the amount of eNOS protein as reflected in eNOS immunofluorescence intensity in bovine aortic endothelial cells. Data from Ranjan et al. (107). *P < 0.05 vs. static. C: dose-response relationship of the effects of shear stress on eNOS mRNA polyadenylation. Increasing amounts of shear produce progressively longer transcripts. *P < 0.05 vs. dyn/cm2. D: increasing the duration of exposure of endothelial cells to shear stress also results in increased eNOS mRNA polyadenylation. Increasing duration of shear stress exposure at 15 dyn/cm2 produce progressively longer transcripts. *P < 0.05 vs. 0 h. **P < 0.05 vs. 0 h. Data for A, C, and D are taken with permission from Weber et al. (135) and data illustrated in B are taken from Ranjan et al. (107).