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. Author manuscript; available in PMC: 2012 Feb 28.

Published in final edited form as: J Appl Physiol (1985). 2007 Dec 6;104(3):588–600. doi: 10.1152/japplphysiol.01096.2007

Table 2.

Cyclic strain effects on markers of endothelial cell inflammation, adhesion, and phenotype

		Stimulus
Study	Model	Cyclic Strain, %	Duration, h	Cyclic Strain Effects (vs. static)
Awolesi et al. (2)	BAEC on flexible membrane	10 and 24%	24	● ↑ eNOS activity
Awolesi et al. (2)	BAEC on flexible membrane	10 and 24%	24	● ↑ eNOS protein
Awolesi et al. (3)	BAEC on flexible membrane	6 and 10%	0–24	● ↑ eNOS mRNA
Awolesi et al. (3)	BAEC on flexible membrane	6 and 10%	0–24	● ↑ eNOS protein
Wung et al. (141)	HUVEC on flexible membrane	12%	0.5, 1, and 24	● ↑ $O_{2}^{-}$ production
Wung et al. (141)	HUVEC on flexible membrane	12%	0.5, 1, and 24	● ↑ MCP-1
Wung et al. (142)	HUVEC on flexible membrane		0.5 and 2	● ↑ NO production
Wung et al. (142)	HUVEC on flexible membrane		0.5 and 2	● ↓ $O_{2}^{-}$ signaling of MCP-1
Cheng et al. (14)	HUVEC on flexible membrane	9, 11, and 12%	24–48	● ↑ soluble ICAM-1 release
				● ↑ surface ICAM-1 expression
				● ↑ ICAM-1 mRNA
Cheng et al. (15)	HUVEC on flexible membrane	12%	0.25–20	● ↑ ICAM-1 mRNA
				● ↑ $O_{2}^{-}$ production
				● ↑ antioxidant activity
Yun et al. (145)	HUVEC on flexible membrane	15 and 25%	0.5–24	● ↑ E-selectin expression
				● ↑ ICAM-1 expression
				● ↑ monocyte adhesion
Ziegler et al. (148)	Perfused BAEC silicon tubes	4%	24	● ↓ eNOS promoter activation
Ziegler et al. (148)	Perfused BAEC silicon tubes	4%	24	● No change in eNOS mRNA
Ziegler et al. (147)	Perfused BAEC silicon tubes	4%	1, 4, and 24	● No change in ET-1 mRNA
Ziegler et al. (147)	Perfused BAEC silicon tubes	4%	1, 4, and 24	● No change in eNOS mRNA