Table 1.
Parameter | p90 | p130 | p130 + l-NNA | p130 + l-NNA + Indo |
---|---|---|---|---|
Maximum diameter, µm | ||||
Young | 182.4±11.4 | 166.1±15.6 | 171.2±6.9 | 191.1±13.9 |
Old | 188.9±11.1 | 192.5±11.6 | 177.2±15.2 | 164.0±13.3 |
Initial tone, % | ||||
Flow | ||||
Young | 47.0±5.5 | 54.8±8.4 | 69.7±6.3 | 62.6±6.4 |
Old | 54.6±9.5 | 51.7±5.8 | 64.0±4.8 | 57.6±9.9 |
ACh | ||||
Young | 34.4±4.2 | 54.4±11.9 | 82.3±4.6†‡ | 70.8±10.4† |
Old | 45.9±9.8 | 46.1±7.3 | 68.6±4.4* | 68.5±8.8 |
Values are means ± SE; n = 8–9 rats/group [young (4 mo old) and old (24 mo old)]. SFA, soleus muscle feed arteries; l-NNA, Nω-nitro-l-arginine; Indo, indomethacin; p90 and p130, normal (90 cmH2O) and high (130 cmH2O) intraluminal pressure, respectively.
P ≤ 0.05 vs. young.
P ≤ 0.05 vs. p90.
P ≤ 0.05 vs. p130.