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The Two-Tier Model of IL-17 Receptors and TRAF3IP2 Expression. in Human and Mouse Tissues. Tissues in the first tier expression status will secrete pro-inflammatory cytokines and chemokines to induce inflammation in response to IL-17 cytokine stimulation while tissues in the second tier need up-regulation of at least one component in the IL-17 receptor complex to induce secretion of pro-inflammatory cytokines and chemokines to drive the inflammatory process.
