Table 4.
Alternative promoter and alternative splicing regulate the expression and structures of IL-17 cytokines and receptors
| A. Alternative promoter and alternative splicing regulate the expression and structures of IL-17 Cytokines | ||||||
|---|---|---|---|---|---|---|
| Gene | Exon(s) | Total Isoform(s) | ORF Isoform(s) | IL-17 domain /secreted | Promoter(s) | |
| IL-17A | 3 | 1 | 1 | 1 | 1 | |
| IL-17B | 6 | 3 | 3 | 2 | 2 | |
| IL-17C | 4 | 2 | 2 | 1 | 1 | |
| IL-17D | 8 | 5 | 5 | 2 | 3 | |
| IL-17E | 3 | 2 | 2 | 2 | 1 | |
| IL-17F | 3 | 2 | 2 | 1 | 2 | |
| IL-17a | 3 | 1 | 1 | 1 | 1 | |
| IL-17b | 8 | 7 | 7 | 4 | 4 | |
| IL-17c | 2 | 1 | 1 | 1 | 1 | |
| IL-17d | 3 | 3 | 2 | 2 | 1 | |
| IL-17e | 3 | 1 | 1 | 1 | 1 | |
| IL-17f | 9 | 4 | 4 | 2 | 2 | |
| B. Alternative promoter and alternative splicing regulate the expression and structures of IL-17 receptors | ||||||
| Gene | Exon(s) | Total Isoform(s) | ORF Isoform(s) | Secreted | SEFIR domain | Promoter(s) |
| IL-17RA | 33 | 23 | 18 | <18 | 3 | |
| IL-17RB | 11 | 2 | 1 | 1 | 11 | |
| IL-17RC | 39 | 28 | 26 | 5 | <26 | 4 |
| IL-17RD | 18 | 5 | 4 | <4 | 1 | |
| IL-17RE | 13 | 1 | 1 | 1 | 11 | |
| IL-17ra | 14 | 4 | 3 | 1 | <3 | 1 |
| IL-17rb | 11 | 1 | 1 | 1 | 11 | |
| IL-17rc | 20 | 7 | 7 | <7 | 2 | |
| IL-17rd | 12 | 1 | 1 | 1 | 11 | |
| IL-17re | 23 | 11 | 11 | 3 | <11 | 2 |
Of note: The data were retrieved from the NIH-NCBI-AceView database except those marked with 1, which were retrieved from the NIH-NCBI-Gene database. AceView-NCBI database was used to examine alternative promoter and alternative spliced isoforms of genes. A majority of the IL-17 cytokine and receptor genes in both human and mouse has numerous isoforms. Many of the genes have alternative promoters and more than one open reading frame (ORF) suggesting that alternative promoters and alternative splicing regulate the structure and expression of IL-17 cytokines and receptors. Human cytokine and receptor family members are designated with capital letters while mouse cytokine and receptor family members are denoted with lowercase letters.