Fig. 2.

Left: clustering analysis of all genes (n = 533, corresponding to 608 probes) significantly altered at least once in the 1–8 h course of pancreatic growth (up or down at any point). Gene cluster into 7 groups with temporally distinct patterns (A–G). A: peak at 2–8 h; B: up at 4 h and/or 8 h; C: peak at 1–2 h; D: up at 4–8 h; E: decreased at 2–8 h; F: down at 4 h; G: slow decrease with max trough at 8 h. Green arrows point to 38 calcineurin (CN)-dependent (FK506-inhibited) genes. Right: graphical representation of 12 random genes within a cluster (black lines) and averaged time course of all genes within a cluster (red line) shown as fold induction (log 10 scale) at 1–8 h vs. fasted controls.