Table 2.
Genes differentially regulated in PI-refed vs. fasted mice
| GenBank Accession | Gene Symbol | Product | Functional Annotation | PI vs. Fast (fold up) | |
|---|---|---|---|---|---|
| ↑ 1 h | NM_019466.1 | Rcan1 | regulator of calcineurin 1 | calcium signaling, phosphatase regulator, muscle development | 164 |
| NM_020013.1 | Fgf21 | fibroblast growth factor 2 | growth factor, extracellular space | 32.1 | |
| NM_010415.1 | HbEGF | heparin binding EGF-like GF | angiogenesis, cell migration, proliferation | 27.8 | |
| AY061760.1 | Nfil3 | nuclear factor, interleukin 3, regulated | transcriptional regulator, rhythmic process | 22.1 | |
| BC019946.1 | Atf3 | activating transcription factor 3 | transcriptional regulator, positive regulation of cell proliferation | 20.4 | |
| ↑ 2 h | BB241535 | Socs3 | suppressor of cytokine signaling 3 | JAK-STAT. negative regulator of signaling, organ regeneration | 43.6 |
| BG067321 | Rgs2 | regulator of G protein signaling 2 | cell cycle, negative regulator of signaling | 22.2 | |
| BB049138 | Pvr | poliovirus receptor | cell-cell adhesion, cell migration | 21.6 | |
| NM_011819.1 | Gdf15 | growth differentiation factor 15 | catabolism, stress response | 20.4 | |
| NM_008416.1 | Junb | Jun-B oncogene | vasculogenesis, transcription, blood vessel development | 19.2 | |
| Repeat: Rcan1, FGF21 | 71.7, 20.0 | ||||
| ↑ 4 h | AF356876.1 | Acat2 | acetyl-Coenzyme acyltransferase 2 | metabolic process | 36.9 |
| AI323528 | Gadd45b | growth arrest and DNA-damageinducible 45 beta | cell cycle, negative regulator of signaling | 18.0 | |
| NM_007913.1 | Egr1 | early growth response 1 | activation of MAPKK activity, cell differentiation | 16.4 | |
| BC028271.1 | Pitpnc1 | phosphatidylinositol transfer protein | transports, signal transduction+ | 16.4 | |
| BF318536 | Tcrb-J | T-cell receptor beta, joining | immune response | 15.1 | |
| Repeat: Rcan1 | 32.7 | ||||
| ↑ 8 h | BB535494 | Nedd9 | neural precursor cell expressed, downregulated gene 9 | cell cycle, regulation of growth | 33.2 |
| BB479063 | Ldb3 | LIM domain binding 3 | 31.6 | ||
| NM_009789.1 | S100 g | S100 calcium binding protein G | calcium-mediated signaling | 24.2 | |
| NM_018792.1 | Hils1 | histone H1-like protein in spermatids 1 | transcription, organismal development | 23.3 | |
| AA589629 | Slc6a6 | solute carrier family 6, member 6 | beta-alanine transport, taurine transport | 23.1 | |
| Repeat: Rcan1, Acat2, Pitpnc1 | 51.2, 35.6, 32.8 | ||||
| ↓ 1 h | BG076140 | Sesn1 | sestrin 1 | cell cycle arrest | 0.17 |
| NM_023719.1 | Txnip | thioredoxin interacting protein | transcriptional regulator, response to oxidative stress, cell cycle | 0.21 | |
| ↓ 2 h | AK005023.1 | Sel1l | sel-1 suppressor of lin-12-like (C. elegans) | Notch signaling pathway | 0.14 |
| BF687395 | Aass | aminoadipatesemialdehyde synthase | metabolic process, oxidation reduction | 0.24 | |
| NM_013873.1 | Sult4a1 | sulfotransferase family 4A, member 1 | lipid metabolism, steroid metabolism | 0.27 | |
| BM934224 | Cyb5b | cytochrome b5 type B | transport, electron transport chain | 0.28 | |
| Repeat: Sesn1 | 0.17 | ||||
| ↓ 4 h | BC014714.1 | Hmgcs2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | response to nutrient, response to peptide hormone stimulus | 0.01 |
| BC018220.1 | Dym | dymeclin | 0.03 | ||
| NM_016772.1 | Ech1 | enoyl coenzyme A hydratase 1 | lipid metabolic process+ | 0.05 | |
| BB703414 | Higd1c | HIG1 domain family, 1C | metabolic process | 0.06 | |
| BC019410.1 | Abhd14b | abhydrolase domain containing 14b | 0.08 | ||
| ↓ 8 h | AI196411 | Gsta3 | glutathione S-transferase, alpha 3 | metabolic process | 0.03 |
| BM227770 | Camk2 g | CAM-dependent protein kinase II gamma | G1/S transition of mitotic cell cycle, protein amino acid phosphorylation | 0.08 | |
| AK019346.1 | Dgcr6 | DiGeorge syndrome critical region gene 6 | 0.11 | ||
| AV171622 | Mettl7a1 | methyltransferas like 7A1 | metabolic process | 0.11 | |
| NM_009752.1 | Glb1 | galactosidase, beta 1 | carbohydrate metabolic process | 0.11 | |
| Repeat: Ech1, Sesn1, Abhd14b, Dym | 0.05, 0.07, 0.08, 0.08 |