Fig. 4.

(A) Fibrillar fraction calculated from the model given in the text (state F) for 39W-69C at pH 7.4, T = 10° C (black line), pH 7.4, T = 40° C (dark gray line), 69C-94W at pH 3.5 (medium gray line), and 39W-69C A30P at pH 7.4, T = 40° C (light gray line) using the rates given in Table 1. The circles are experimental measurements of aggregation of mutant 69C-94W detected by ThT fluorescence (right and top axes) scaled to match the calculated rates (left and bottom axes). (B) Oligomer fraction (state O) calculated from the model using the same rates as A.