Table 1.

Bone density and trabecular microarchitecture in 6- and 16-wk-old TPH₁^−/− and WT mice

	6-wk-old		16-wk-old
	WT	TPH1−/−	WT	TPH1−/−
Bone mineral density (mg/cm2)
BMD whole-body	0.037 ± 0.003	0.042 ± 0.002**	0.055 ± 0.002†††	0.055 ± 0.003†††
BMD femur	0.046 ± 0.006	0.054 ± 0.004*	0.077 ± 0.005†††	0.073 ± 0.005†††
BMD vertebrae	0.040 ± 0.005	0.046 ± 0.002*	0.059 ± 0.001††	0.060 ± 0.003†††
Bone structure
Bone volume/tissue volume (%)	12.76 ± 1.29	21.1 ± 2.63***	13.4 ± 0.6	12.7 ± 1.2
Trabecular separation (μm)	182.15 ± 15.94	117.89 ± 12.69***	221.7 ± 15.9	193.5 ± 25.8**
Trabecular thickness (μm)	26.21 ± 2.19	31.08 ± 2.52*	34.3 ± 2.8	28.3 ± 3.3***
Trabecular number (Tb.N,1/mm)**	5.25 ± 0.4	7.36 ± 0.1***	4.12 ± 0.2	5.56 ± 0.1**

Values are shown as mean ± SD (n = 8 per genotype). *P < 0.01 versus WT, **P < 0.001 versus WT, ***P < 0.0001 versus WT, ^††P < 0.001 versus 16-wk-old mice in the same genotype, ^†††P < 0.0001 versus 16-wk-old mice in the same genotype.