Table 3.

Evaluation of liver toxicity of LM10 in mice

Liver enzyme*	ALAT (IU/mL ± SEM)	ALAP (IU/mL ± SEM)	ASAT (IU/mL ± SEM)	γ-GT (IU/mL ± SEM)
Control†	34.8 ± 2.4	74.4 ± 2.3	106.7 ± 8.8	3.0 ± 0.2
LM10-treated‡	47.5 ± 3.3	92.7 ± 3.0	156.9 ± 8.1	2.8 ± 0.2
Normal range§	21–83	68–89	70–215	1–4

*Enzyme activities were measured in the plasma. ALAP: alkaline phosphatase; γ-GT: γ-glutamyl transferase; ALAT: alanine aminotransferase, ASAT: aspartate aminotransferase.

^†Group of 43 mice from the experiment reported in Fig. 2B, fed with normal drinking water and tested 107 d after tumor challenge. Shown are the compiled results of three independent assays.

^‡Group of 82 mice from the experiment reported in Fig. 2B, fed with a solution of LM10 (1 mg/mL pH 9; 160 mg/kg/day) and tested 107 d after tumor challenge. Shown are the compiled results of three independent assays.

^§Group of 7 untreated normal DBA/2 mice.