Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jan 17;109(7):E406–E414. doi: 10.1073/pnas.1108633109

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 1. — Bioinformatics and experimental workflow used for analysis of the coevolution of PCNA-partner interactions. Changes in the IDCL region of PCNA are analyzed by sequence alignment and PCA (step 1). Next, different chimeric PCNA variants are generated by substitution of the native IDCL region with IDCLs from different species (step 2). Such variants are characterized for PCNA-partner interactions and for in vivo function in S. cerevisiae as a model organism (step 3). Bar indicates a size of 5 microns.