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. 2012 Mar;91(3):401–415. doi: 10.1189/jlb.0811394

Figure 5. HIV-infected monocytes transmigrate exuberantly as compared to uninfected monocytes across the BBB in response to CCL2.

Figure 5.

Maturing monocytes cultured nonadherently with M-CSF in our system, either HIV-infected or uninfected, were added to the top of our in vitro model of the BBB and transmigrated in response to media alone or 200 ng/mL CCL2 for 24 h. CCL2 resulted in significantly higher numbers of HIV-infected transmigrated CD14+CD16+ monocytes relative to baseline and to the transmigration of uninfected cells to CCL2 (*P<0.03; n=5). There was also significant transmigration of uninfected monocytes in response to CCL2 (*P<0.03; n=5). Baseline transmigration was similar for the HIV-infected and uninfected mature monocytes.