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Primary sequence of IAPP. Shown are human and rat sequences of IAPP, with amino acid differences indicated in bold. Large horizontal arrows indicate areas of unambiguous secondary structure reported for both hIAPP and rIAPP on membranes (14) and for fibrillar states of hIAPP (32). Small arrows indicate additional constructs assayed in this work: hIAPPL12N/N14L, hIAPPH18R, and rIAPPR18H.
