Figure 8.

Extensive and frequent Z-line streaming regions in soleus of Hom T4826I-RYR1 males. A, B) In areas of Z-line streaming, i.e., a structural disarrangement of Z lines in elongated patches, all elements of the sarcomere are markedly altered, with loss of thin and thick filament, sarcomere misalignment, and a very disordered cross striation (A) and enlargement (B). In addition, all structural elements (SR/T-tubules and mitochondria) are totally missing in these areas. C) In cross sections, these alterations appear as cores, by the classic definition of this structural alteration.