. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Jan 24;22(5):1985–1988. doi: 10.1016/j.bmcl.2012.01.029

Table 4.

Antiparasitic activity of selected compounds.

Compound	T. gondii model^a			C. parvum model
	EC₅₀(μM)		Selectivity	C. parvum model
	Toxo/WT	Toxo/CpIMPDH	Selectivity	EC₅₀ (μM)
C64	>23	0.3 ± 0.1	>73	0.7 ± 0.2^c
C84	3 ± 2	0.7 ± 0.3	5	1.7 ± 0.8^c
C90	5 ± 1	0.6 ± 0.1	9	0.9 ± 0.5
C91	2.7 ± 0.9^c	0.3 ± 0.2	9	n.d.
C97	17 ± 9	0.5 ± 0.4	30	< 0.8^d

All values are the average of three independent trials unless otherwise stated.

T. gondii model¹². Toxo/WT, strain with endogenous IMPDH; Toxo/CpIMPDH, strain that depends on CpIMPDH. Selectivity = EC₅₀(Toxo/WT)/EC₅₀(Toxo/CpIMPDH);

C. parvum in vitro infection model;

two determinations;

Average growth inhibition 80 ± 10 % at 0.8 μM.