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. 2012 Feb 28;6(2):e1523. doi: 10.1371/journal.pntd.0001523

Figure 1. Dendogram analysis of biogenic amine (BA) G protein-coupled receptors (GPCR).

Figure 1

A rooted phylogenetic tree was constructed from a ClustalW sequence alignment of vertebrate and invertebrate BA receptors, using MEGA 4 [35]. Included in the alignment are 15 predicted Schistosoma mansoni and S. japonicum BA GPCR sequences, of which nine clustered together into a separate clade (SmGPR). The receptor described in this paper, SmGPR-3 is identified by an open square (□). Other S. mansoni receptors are marked with solid squares (▪) and S. japonicum receptors are marked with solid triangles (▴). Sequences are identified by their accession numbers and the species names are abbreviated as follows: A.e. (Aedes aegypti), A.i. (Agrotis ipsilon), A.m. (Apis mellifera), B.m. (Bombyx mori), B.t. (Bos taurus), C.e. (Caenorhabditis elegans), C.f. (Canis familiaris), C.p. (Cavia porcellus), D.m. (Drosophila melanogaster), D.j. (Dugesia japonica), D.r. (Danio rerio), H.s. (Homo sapiens), H.v. (Heliothis virescens), M.b. (Mamestra brassicae), M.m. (Mus musculus), M.mul. (Macaca mulatta), P.a. (Periplaneta americana), P.x. (Papilio xuthus), R.n. (Rattus norvegicus), S.j. (S. japonicum), S.med. (Schmidtea mediterranea), S.l. (Spodoptera littoralis) and S.s. (Sus scrofa). Predicted S. mansoni coding sequences are identified by their “Smp” designation obtained from the S. mansoni Genome database (S. mansoni GeneDB) and the corresponding GenBank Accession number. H1–H4, histamine type 1–4 receptors; D1–D5, dopamine type 1–5 receptors; A, adrenergic receptors; 5HT, serotonin (5-hydroxytryptamine) receptors; mACh, muscarinic acetylcholine receptors; OA/TA, octopamine/tyramine receptors.