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. 2012 Feb 28;7(2):e31793. doi: 10.1371/journal.pone.0031793

Table 4. Effect of estimates of cupping for acne in 6 RCTs.

Trials Comparisons Effect Estimates ([95%CI]) P
Numbers of cured patients
Wet cupping plus other interventions versus other interventions alone
Wet cupping plus herbal medicine versus herbal medicine alone
Huang J 2010 [38] Wet cupping plus herbal preparation, topical cream versus herbal preparation and external cream RR 2.06 [1.33, 3.18]
Subgroup RR 2.06 [1.33, 3.18] 0.001
Wet cupping plus acupuncture versus acupuncture alone
Liu H 2009 [59] Flash cupping plus acupuncture versus acupuncture alone RR 1.91 [0.99, 3.72]
Wang Q 2007 [91] Moving and wet cupping plus acupuncture versus acupuncture alone RR 1.67 [0.87, 3.20]
Subgroup RR 1,79 [1.12, 2.86] 0.01
Overall (Fixed, I2  = 0%) RR 1.93 [1.40, 2.65] <0.0001
Wet cupping versus medications
Wu F 2010 [95] Wet cupping versus tanshinone RR 1.07 [0.45, 2.56]
Wu Y 2008 [97] Wet cupping versus tetracycline and ketoconazole cream RR 2.50 [1.31, 4.77]
Zhang K 2008 [125] Wet cupping versus tetracycline RR 2.75 [1.38, 5.48]
Overall (Fixed, I2  = 37%) RR 2.14 [1.42, 3.22] 0.0003
Average cure time
Cupping plus other intervention versus other interventions alone
Li W 2005 [51] Wet cupping plus TDP, antivirus and neurotrophic drugs versus TDP and drugs alone MD −4.14 [−5.74, −2.54]
Qiu J 2003 [76] Medicinal cupping plus neurotrophic drugs versus neurotrophic drugs alone MD −8.00 [−9.78, −6.22]
Overall (Random, I2  = 90%) MD −6.05 [−9.83, −2.27] 0.002
Wet cupping versus medications
Zhu F 2009 [141] Wet cupping versus antivirus and neurotrophic drugs MD −7.20 [−14.27, −0.13]
Overall MD −7.20 [−14.27, −0.13] 0.05