Figure 5. r-hPAP has antinociceptive properties in vivo.

Antinociceptive properties of native hPAP, r-hPAP and r-hPAP (N62Q, N188Q) injected intrathecally into wild-type (n = 10) and A₁R ^−/− mice (n = 10). Equivalent unit amounts (250 mU/mouse) of native hPAP and r-hPAP were injected. Equivalent protein amounts (0.21 mg/mL) of r-hPAP and r-hPAP (N62Q, N188Q) were injected. Paired t-tests were used to compare responses at each time point to baseline (BL). *p<0.05, **p<0.005, ***p<0.0005. Data are plotted as means ± standard error of the mean (SEM).