Figure 6. r-hPAP does not affect balance or motor function in mice.

Rotarod tests with wild-type (n = 10) and A₁R^−/− mice (n = 10) 24 h before (3 iterations, separated by 40 s) and 24 h after (2 test iterations, separated by 40 s) intrathecal injection of r-hPAP (250 mU/mouse). No significant differences between genotypes or treatment. Data are plotted as means ± SEM. The same mice shown were also tested for thermal sensitivity, to confirm that hPAP injections were successful (as evidenced by a significant thermal antinociceptive effect in wild-type mice injected with hPAP, data not shown).