Figure 8. Antinociceptive effects of r-hPAP in neuropathic pain model.

(A, B) The sural and common peroneal branches of the sciatic nerve were ligated and then transected (injure-arrow) in wild-type (n = 10) and A₁R^−/− mice (n = 10). Six days later, r-hPAP (250 mU) was injected intrathecally. Injured and non-injured (control) hindpaws were tested for (A) thermal and (B) mechanical sensitivity. Data are plotted as means ± SEM. Paired t-tests were used to compare responses at each time point between genotypes, same paw comparisons. *p<0.05, **p<0.005, ***p<0.0005.