TABLE 2.

Comparison of Reciprocal Relationships between CAF and CD133+ or CD133− Colon Cancer Cells

A. CD133+ vs. CD133− cells
RECEPTOR (Gene Symbol)		p-value	Fold Change
CXCR4	chemokine (C-X-C motif) receptor 4	0.02*	4.07
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.04*	3.12
ITGB8	integrin, beta 8	0.01*	2.18
FGFR2	Fibroblast growth factor 2	0.03*	1.21
LIGAND
CXCL12	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	0.89	1.02
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.88	1.01
VTN	vitronectin	0.82	−1.04
FGF ligands 1,2,7,5,13,	fibroblast growth factor ligands	N.S.

B. CAF vs. CD133+ or CD133− cells
LIGAND		CAF vs CD133+ p-value	CAF vs CD133+ Fold change
		CAF vs CD133− p-value	CAF vs CD133− Fold change
CXCL12	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	0.0003*	3.73
		0.0002*	3.8
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	3.71E-05*	1.87
		4.01E-5*	1.85
VTN	vitronectin	1.54E-05*	7.29
		1.72E-05*	7.03
FGF2	fibroblast growth factor 2 (basic)	1.49E-09*	28.32
		1.48E-09*	28.51
FGF7	fibroblast growth factor 7 (keratinocyte growth factor)	3.52E-07*	15.35
		3.52E-07*	15.36
FGF13	fibroblast growth factor 13	3.26E-07*	8.10
		5.22E-07*	7.9
FGF5	fibroblast growth factor 5	2.83E-05*	2.57
		3.50E-05*	2.48
FGF1	fibroblast growth factor 1	7.48E-05*	2.12
		3.53E-05*	2.35

C. CD133+ or CD133− Cells vs.CAF
RECEPTOR (GENE SYMBOL)		CD133+ vs. CAF p-value	CD133+ vs. CAF Fold change
		CD133− vs. CAF p-value	CD133− vs. CAF Fold change
CXCR4	chemokine (C-X-C motif) receptor 4	0.007*	5.26
		0.56	1.29
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.03*	3.32
		0.89	1.06
ITGB8	integrin, beta 8	0.009*	2.04
		0.73	−.107
FGFR2	Fibroblast growth factor 2	0.005*	1.48
		0.015*	1.22

^*Statistical significance demonstrated at p-value ≤ 0.05