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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Haemophilia. 2011 Sep 20;18(3):e316–e322. doi: 10.1111/j.1365-2516.2011.02648.x

Figure 1.

Figure 1

Figure 1

Figure 1

Figure 1

The temporal relationship of thrombin generation and TAFI activation in subjects grouped by their fVIII level at the time of blood collection. Thrombin-antithrombin (●) and TAFIa (○) were assayed over time in whole blood from controls (panel A), and haemophilic subjects with > 5% fVIII (B), 1-5% fVIII (C) and < 1% fVIII (D). The maximal concentration of thrombin-antithrombin and the rate of TAT formation decreased as the fVIII concentration decreased. Similarly, both the rate and maximal concentration of TAFIa decreased as the fVIII concentration decreased. In all groups, TAFI activation was slightly delayed compared to thrombin generation. In each panel the clot time is denoted by an arrow. Data are presented as the mean ± standard error.