Table 1.
Clinical bleeding phenotype and fVIII level at the time of blood collection.
| Subject | fVIII (%) |
Hemarthrosis Score Mean (SD) |
Soft Tissue Score Mean (SD) |
FVIII Replacement Score Mean (SD) |
Total Score Mean (SD) |
|---|---|---|---|---|---|
| Mild 1 | 21 | 0 | 2 | 0 | 2 |
| Mild 2 | 16 | 0 | 2 | 1.5 | 3.5 |
| Mild 3 | 51 | 0 | 0 | 0 | 0 |
| Mild 4 | 35 | 0.0 | 0.3 (0.3) | 0.5 (0.5) | 0.8 |
| Mild 5 | 6 | ND | ND | ND | ND |
| Mild 6 | 5 | ND | ND | ND | ND |
| Mod 1 | 4 | 0.4 (0.4) | 0.3 (0.3) | 0.9 (0.6) | 1.6 |
| S1 | 16 | 12.0 | 6.4 (1) | 12.0 | 30.4 (1) |
| S2 | 10 | 3.0 | 8.0 | 5.4 (0.6) | 16.4 (0.6) |
| S3 | 22 | 2.5 (0.9) | 0 | 9 (1.3) | 11.5 (0.9) |
| S4 | 10 | 9.6 (1.1) | 4.8 (0.8) | 6 | 20.4 (1.3) |
| S5 | 11 | 6 (1.8) | 3.3 (1.5) | 6.0 | 15.3 (3) |
| S6 | 2.4 | 1.2 (1.2) | 2.8 (0.5) | 3.0 | 7 (1.5) |
| S7 | 1.65 | 6 (3) | 3.3 (2.4) | 6.0 | 15.3 (5.4) |
| S8 | 1.2 | 8 (1) | 8.0 | 6.0 | 22 (1) |
| S9 | 1 | 5.4 (0.6) | 2.4 (0.4) | 6 | 13.8 (0.8) |
| S10 | 4 | 2 (0.6) | 1.7 (0.6) | 6.0 | 9.7 (0.8) |
| S11 | 1 | 10.8 (0.7) | 2.8 (0.8) | 6 | 19.6 (1.3) |
| S12 | 3 | 7 (1.3) | 2.7 (1) | 4.5 (0.7) | 14.2 (2.4) |
| S13 | 0.42 | 7.8 (1.2) | 3.2 (0.8) | 6.0 | 17 (0.6) |
| S14 | 0.42 | 0.6 (0.6) | 1.6 (0.7) | 6.0 | 8.2 (1.3) |
| S15 | 0.24 | 9.6 (0.6) | 3.2 (1) | 3.0 | 15.8 (1.3) |
| S16 | 0.16 | 3 (1.7) | 1.3 (1.3) | 12.0 | 16.3 (2.2) |
| S17 | 0.18 | 8.4 (1.1) | 5.2 (1) | 12.0 | 25.6 (2.1) |
| S18 | 0.42 | 2 (1) | 3.3 (1.3) | 6.0 | 11.3 (0.3) |
| S19 | 0.07 | 1.5 (0.9) | 0.0 | 7.5 (1.5) | 9 (2.1) |
| S20 | 0.1 | 3.6 (0.6) | 4 (0.6) | 9.6 (1.5) | 17.2 (1.6) |
| S21 | 0.16 | 4.8 (1.4) | 7.2 (0.9) | 5.4 (0.4) | 17.4 (0.8) |
ND: Not determined, Mild=Mild, Mod=Moderate and S=Severe by original diagnosis.