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Enhancement of topoisomerase IIα-mediated DNA cleavage by 4-methyl-m-AMSA. The effects of 4-methyl-m-AMSA (open circles) on the cleavage of negatively supercoiled plasmid DNA by human topoisomerase IIα are compared to those of m-AMSA (closed circles). Error bars represent the standard deviation of three independent experiments. The inset shows a representative topoisomerase I-based intercalation assay for 4-methyl-m-AMSA.
