Table 2.

Associations of p53-related genetic variants with risk of HPV16 associated oral cancer

		Cases (n = 320)		Controls (n = 321)
Variables	HPV16 Status	No.	%	No.	%	Adj. OR (95% CI)*
P53
Arg/Arg	−	130	40.6	144	44.8	1.0
Arg/Pro + Pro/Pro	−	91	28.4	136	42.4	0.7 (0.5–1.1)
Arg/Arg	+	43	13.7	24	7.5	2.0 (1.1–3.6)
Arg/Pro + Pro/Pro	+	56	17.5	17	5.3	3.6 (2.0–6.6)
P73
GC/GC	−	132	41.2	171	53.3	1.0
GC/AT + AT/AT	−	89	27.8	109	34.0	1.0 (0.7–1.4)
GC/GC	+	54	16.9	26	8.1	2.7 (1.6–4.6)
GC/AT + AT/AT	+	45	14.1	15	4.8	3.7 (2.0–7.0)
MDM2-rs2279744
GT + GG	−	125	39.1	188	58.6	1.0
TT	−	96	30.0	92	28.7	1.6 (1.1–2.3)
GT + GG	+	50	15.6	27	8.4	2.8 (1.7–4.8)
TT	+	49	15.3	14	4.3	5.5 (2.9–10.5)
MDM2-rs937283
AA	−	49	15.3	94	29.3	1.0
AG + GG	−	172	53.7	186	57.9	1.8 (1.2–2.8)
AA	+	20	6.3	17	5.3	2.2 (1.0–4.6)
AG + GG	+	79	24.7	24	7.5	6.8 (3.8–12.2)
MDM4-rs10900598
GT + TT	−	153	47.8	195	60.7	1.0
GG	−	68	21.3	85	26.5	1.0 (0.7–1.5)
GT + TT	+	60	18.7	32	10.0	2.4 (1.5–3.8)
GG	+	39	12.2	9	2.8	5.9 (2.7–12.7)
MDM4-rs1380576
CC	−	109	34.1	133	41.4	1.0
CG + GG	−	112	35.0	147	45.8	0.9 (0.6–1.3)
CC	+	32	10.0	16	5.0	2.5 (1.3–4.9)
CG + GG	+	67	20.9	25	7.8	3.2 (1.9–5.6)
MDM4-rs11801299
GG	−	137	42.8	173	53.9	1.0
AG + AA	−	84	26.3	107	33.3	1.0 (0.7–1.4)
GG	+	58	18.1	28	8.7	2.6 (1.6–4.3)
AG + AA	+	41	12.8	13	4.1	4.2 (2.1–8.3)

^*ORs were adjusted for age, sex, smoking and alcohol drinking.