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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: ACS Nano. 2012 Jan 20;6(2):1260–1267. doi: 10.1021/nn203895n

Figure 4.

Figure 4

Non-invasive in vivo PA images (maximum intensity projections, MIP) of the SLN in a rat. a) Photograph of the rat with region of interest depilated before scanning. The scanning region is delineated by a black dotted square. b) Baseline PA image acquired before NanoCuN injection. Bright regions represent inherent optical absorption from a blood vessel (BV). c) PA image (MIP) acquired almost immediately after NanoCuN administration. d) 60 min post-injection PA image showing a marked signal enhancement corresponding to increased NanoCuN uptake by the node: Blood vessel (BV) and sentinel lymph node (SLN) are marked with arrows. The SLN is visible in both c) and d), however, not apparent in b). e) Photograph of the rat with the skin excised after PA imaging. For b)–d): FOV = 25 mm × 24 mm, step size along the X direction = 0.2 mm, step size along the Y direction = 0.4 mm, total scan time=~23 min. No signal averaging was used.