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Antibody responses to OVA-Q11 were T cell-dependent. T cell receptor knockout mice (TCR KO, Tcrb−/−Tcrd−/−), did not produce antibodies detectable by ELISA against OVA-Q11, but they did respond to a known T-independent antigen, nitrophenyl-Ficoll (NP-Ficoll). WT mice responded to both OVA-Q11 and NP-Ficoll.
