Table 2.
Blood gas parameters
| Hct % |
Hb g/dL |
pH | PO2 mmHg |
PCO2 mmHg |
BE mmol/L |
|
|---|---|---|---|---|---|---|
| Baseline | ||||||
| HSA | 47.5 ± 2.4 | 14.4 ± 0.6 | 7.34 ± 0.02 | 60 ± 9 | 56 ± 8 | 3.7 ± 2.0 |
| PolyHSA24:1 | 48.8 ± 3.0 | 14.8 ± 0.7 | 7.35 ± 0.02 | 62 ± 10 | 57 ± 7 | 4.1 ± 2.3 |
| PolyHSA60:1 | 48.7 ± 3.2 | 14.9 ± 0.9 | 7.36 ± 0.02 | 57 ± 6 | 56 ± 7 | 4.0 ± 2.0 |
| PolyHSA94:1 | 48.4 ± 2.4 | 14.6 ± 0.7 | 7.36 ± 0.02 | 62 ± 5 | 54 ± 2 | 4.8 ± 1.7 |
| Shock | ||||||
| PolyHSA24:1 | 28.2 ± 1.1 | 9.4 ± 0.5 | 7.24 ± 0.12 | 95 ± 11 | 39 ± 7 | −4.8 ± 2.2 |
| PolyHSA24:1 | 28.4 ± 1.0 | 9.5 ± 0.7 | 7.21 ± 0.13 | 97 ± 12 | 38 ± 6 | −5.9 ± 2.4 |
| PolyHSA60:1 | 28.6 ± 0.9 | 9.4 ± 0.8 | 7.22 ± 0.09 | 94 ± 8 | 39 ± 7 | −4.6 ± 2.0 |
| PolyHSA94:1 | 28.0 ± 1.4 | 9.6 ± 0.7 | 7.22 ± 0.08 | 92 ± 10 | 38 ± 7 | −4.9 ± 2.4 |
| Resuscitation 60 min | ||||||
| PolyHSA24:1 | 18.2 ± 1.0 | 5.6 ± 0.5 | 7.38 ± 0.04 | 76 ± 6 | 46 ± 5 | 2.3 ± 1.5 |
| PolyHSA24:1 | 19.3 ± 1.2 | 6.1 ± 0.5 | 7.38 ± 0.06 | 72 ± 9 | 45 ± 6 | 2.1 ± 1.6 |
| PolyHSA60:1 | 21.3 ± 1.4† | 6.7 ± 0.8† | 7.37 ± 0.04 | 76 ± 11 | 47 ± 5 | 3.0 ± 1.3 |
| PolyHSA94:1 | 25.1 ± 1.3†‡§ | 7.9 ± 0.7†‡§ | 7.35 ± 0.04 | 93 ± 6†‡§ | 43 ± 6 | −0.5 ± 1.6†‡§ |
| Resuscitation 60 min | ||||||
| PolyHSA24:1 | 18.5 ± 1.4 | 5.8 ± 0.3 | 7.35 ± 0.03 | 76 ± 6 | 47 ± 6 | 2.2 ± 1.5 |
| PolyHSA24:1 | 18.8 ± 1.2 | 6.0 ± 0.6 | 7.36 ± 0.04 | 80 ± 8 | 46 ± 5 | 1.8 ± 1.4 |
| PolyHSA60:1 | 19.3 ± 1.1† | 6.2 ± 0.5† | 7.39 ± 0.03 | 74 ± 10 | 49 ± 7 | 3.2 ± 1.6 |
| PolyHSA94:1 | 25.0 ± 1.3†‡§ | 7.7 ± 0.7†‡§ | 7.35 ± 0.03 | 81 ± 8†‡§ | 42 ± 6 | −0.7 ± 1.5†‡§ |
Values are means ± SD. Baseline and moderated hemodilution (MH) included all the animals. No significant differences were detected between baseline or during shock between groups. Hct, hematocrit; Hb, hemoglobin; PO2, arterial partial O2 pressure; PCO2, arterial partial pressure of CO2; BE, arterial base excess.
†
P<0.05 compared to HSA;
‡
P<0.05 compared to polyHSA24:1;
§
P<0.05 compared to polyHSA60:1.