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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Vasc Surg. 2011 Nov 25;55(3):815–822. doi: 10.1016/j.jvs.2011.08.038

Figure 6. Schematic representation of our findings.

Figure 6

Fibrinolysis and thrombus resolution were found to be impaired in mice with hyperlipidemia undergoing DVT. Increased PAI-1 contributes to an early increase in thrombus size, due to impaired fibrinolysis. Additionally, undetectable levels of u-PA led to decreased vein wall MMP-2 and MMP-9, and lower levels of MCP-1 affecting monocyte recruitment, thus impairing thrombus resolution.