Table 2.
Effect of oral ingestion of aspirin on the blood pressures and on the dermcidin levels in hypertensive subjects.
| Hypertensive subjects | ||||||||
|---|---|---|---|---|---|---|---|---|
| Before aspirin ingestion | After aspirin ingestion | |||||||
| Parameters | Dermcidin(pmol/mL) | Systolic blood pressure (mm of Hg) | Diastolic blood pressure (mm of Hg) | NO (nmol/h) | Dermcidin (pmol/mL) | Systolic blood pressure (mm of Hg) | Diastolic blood pressure (mm of Hg) | NO (nmol/h) |
| Range | 43.1–175 | 150–180 | 85–110 | 0.4 ± 0.19 | 2.9–51 | 115–140 | 75–85 | 1.9 ± 0.5 |
| Median | 98 | 160 | 90 | 19.1 | 130 | 80 | ||
“Pearson r" (correlation coefficient) = + 0.924 and = + 0.909 between dermcidin level and systolic and diastolic pressures, respectively, before aspirin ingestion.
“Pearson r" (correlation coefficient) = + 0.689 and + 0.846 between dermcidin level and systolic and diastolic pressures, respectively, after the ingestion of aspirin.
The significance (P value) was P < 0.005 between dermcidin levels, systolic and diastolic pressures in hypertensive subjects before and after aspirin ingestion as determined by the Mann Whitney U test with the medians significantly different.
Hypertensive subjects (n = 74) were asked to swallow one 150 mg of aspirin with water after having a meal as described in Section 2. Both the blood pressures and dermcidin levels were determined before the ingestion of aspirin and 3 h after the ingestion of the compound.