Table 10.
Subjects included | H1 (CC) | H2 (CT) | H3 (GC) | H4 (GT) | P (a) | |
---|---|---|---|---|---|---|
IBD N (%) | 77 | 132.9 (86.3) | 7.1 (4.6) | 3.1 (2.0) | 10.9 (7.0) | 0.89 |
OR (C.I.) | 1.13 (0.65–1.94) | 1.16 (0.46–2.9) | 0.77 (0.21–2.81) | 0.81 (0.40–1.67) | ||
Controls (b) | 179 | 303.6 (84.8) | 14.4 (4.0) | 9.4 (2.6) | 30.6 (8.5) | |
UC N (%) | 9 | 17.0 (94.4) | 0.0 (0.001) | 0.0 (0.001) | 1.0 (5.5) | 0.65 |
OR (C.I.) | 0.02 (0.0–439897.28) | 0.03 (0.0–739520.9) | 0.57 (0.07–4.52) | |||
Controls (b) | 117 | 195.8 (83.7) | 10.2 (4.4) | 6.2 (2.7) | 21.8 (9.3) | |
CD N (%) | 68 | 115.8 (85.2) | 7.2 (5.3) | 3.2 (2.3) | 9.8 (7.2) | 0.90 |
OR (C.I.) | 0.86 (0.43–1.74) | 1.6 (0.47–5.51) | 0.91 (0.19–4.42) | 1.02 (0.40–2.61) | ||
Controls (b) | 72 | 107.8 (87.0) | 4.2 (3.3) | 3.2 (2.5) | 8.8 (7.1) | |
| ||||||
D1 (CC/CC) | D2 (CC/GT) | D3 (GC/CT) | D4 (CC/CT) | P (a) | ||
| ||||||
IBD N (%) | 77 | 57.0 (74.0) | 9.9 (12.8) | NP | 6.0 (7.8) | |
OR (C.I.) | 1.17 (0.64–2.13) | 0.81 (0.37–1.76) | 1.08 (0.39–2.95) | |||
Controls (b) | 179 | 127.0 (70.9) | 27.6 (15.4) | NP | 13.0 (7.3) | |
UC N (%) | 9 | 8.0 (88.9) | 1.0 (11.0) | NP | 0.0 (0) | |
OR (C.I.) | 3.56 (0.43–29.49) | 0.65 (0.08–5.53) | — | |||
Controls (b) | 117 | 81.0 (69.2) | 18.8 (16.0) | NP | 9.0 (7.7) | |
CD N (%) | 68 | 49.0 (72.1) | 8.8 (13.0) | NP | 6.0 (8.8) | |
OR (C.I.) | 0.90 (0.41–1.95) | 0.90 (0.33–2.45) | 1.40 (0.38–5.23) | |||
Controls (b) | 72 | 46.0 (74.2) | 8.8 (14.3) | NP | 4.0 (6.5) | |
| ||||||
D5 (CC/GC) | D6 (CT/GT) | D7 (GT/GT) | D8 (GC/GT) | |||
| ||||||
IBD N (%) | 3.0 (3.9) | 1.0 (1.3) | 0.0 (0) | NP | 0.98 | |
OR (C.I.) | 0.77 (0.20–2.91) | — | — | |||
Controls | 9.0 (5.0) | 1.0 (0.6) | 1.0 (0.6) | NP | ||
UC N (%) | 0.0 (0) | 0.0 (0) | 0.0 (0) | NP | 0.67 | |
OR (C.I.) | — | — | — | |||
Controls | 6.0 (5.1) | 1.0 (0.9) | 1.0 (0.9) | NP | ||
CD N (%) | 3.0 (4.4) | 1.0 (1.5) | NP | NP | 0.98 | |
OR (C.I.) | 0.91 (0.18–4.67) | — | ||||
Controls | 3.0 (4.8) | 0.0 (0) | NP | NP |
OR: odds ratio; CI: confidence interval; N: absolute number; H1–H4: haplotype 1—haplotype 4; D1–D8: diplotype 1—diplotype 8; NP: predicted to not appear in the respective case and control group; (a) P values calculated with FAMHAP; (b)the term “controls” denotes here the respective patient subgroup (IBD/UC/CD) without the appearance of fistulas.