Table 5.
Number of variant carriers (12333125A>G and 12415557C>T) in CD and UC patients compared to controls.
| Category | 12333125A>G | ||||||
|---|---|---|---|---|---|---|---|
| Genotype | N (a) | N (%) of SNP carriers | OR (C.I.) | P (c) | OR (C.I) (b) | P (b) | |
| CD | Het plus hom | 143 | 28 (19.6) | 0.68 (0.40–1–15) | 0.15(d) | 0.67 (0.40–1.14) | 0.14 |
| control | Het plus hom | 182 | 48 (26.4) | ||||
| CD | hom | 116 | 1 (0.9) | 0.58 (0.05–6.51) | 1.0 | 0.77 (0.23–2.61) | 0.68 |
| control | hom | 136 | 2 (1.5) | ||||
|
| |||||||
| UC | Het plus hom | 140 | 30 (21.4) | 0.76 (0.45–1.28) | 0.31(d) | 0.78 (0.46–1.32) | 0.35 |
| control | Het plus hom | 182 | 48 (26.4) | ||||
| UC | hom | 111 | 1 (0.9) | 0.61 (0.06–6.81) | 1.0 | 0.70 (0.21–2.38) | 0.57 |
| control | hom | 136 | 2 (1.5) | ||||
|
| |||||||
| 12415557C>T | |||||||
|
| |||||||
| CD | Het plus hom | 139 | 31 (22.3) | 0.91 (0.54–1.54) | 0.72(d) | 0.92 (0.54–1.56) | 0.74 |
| control | Het plus hom | 175 | 42 (24.0) | ||||
| CD | hom | 109 | 1 (0.9) | 0.31 (0.03–2.80) | 0.39 | 0.54 (0.18–1.62) | 0.27 |
| control | hom | 137 | 4 (2.9) | ||||
|
| |||||||
| UC | Het plus hom | 134 | 32 (23.9) | 0.99 (0.59–1.68) | 0.98(d) | 0.94 (0.55–1.62) | 0.83 |
| control | Het plus hom | 175 | 42 (24.0) | ||||
| UC | hom | 104 | 2 (1.9) | 0.65 (0.12–3.63) | 0.70 | 0.84 (0.35–1.99) | 0.69 |
| control | hom | 137 | 4 (2.9) | ||||
OR: odds ratio; CI: confidence interval; N: absolute number; het: heterozygous; hom: homozygous; (a)absolute number of all patients of the respective subgroup included into the analysis; (b)adjusted for age and sex; (c) P values calculated with Fisher's exact test; (d) P value calculated with Chi-Square test.