Table 8.
Subjects included | H1 (CC)(a) | H2 (CT) | H3 (GC) | H4 (GT) | P (c) | |
---|---|---|---|---|---|---|
IBD N (%) | 256 | 436.3 (85.2) | 41.3 (8.1) | 12.7 (2.5) | 21.7 (4.2) | 0.23 |
OR (C.I.) | 1.27 (0.87–1.86) | 0.86 (0.52–1.42) | 0.5 (0.23–1.07) | 1.1 (0.53–2.28) | ||
UC N (%) | 126 | 212.6 (84.4) | 22.6 (9) | 6.4 (2.5) | 10.4 (4.1) | 0.52 |
OR (C.I.) | 1.19 (0.76–1.87) | 0.96 (0.54–1.72) | 0.51 (0.2–1.3) | 1.07 (0.45–2.51) | ||
CD N (%) | 130 | 223.6 (86) | 18.6 (7.2) | 6.4 (2.5) | 11.4 (4.4) | 0.31 |
OR (C.I.) | 1.36 (0.86–2.15) | 0.75 (0.41–1.39) | 0.49 (0.19–1.26) | 1.13 (0.49–2.6) | ||
Controls | 148 | 242.5 (81.9) | 27.5 (9.3) | 14.5 (4.9) | 4.5 (3.9) | |
| ||||||
D1 (CC/CC) (b) | D2 (CC/GT) | D3 (CC/GC) | D4 (CC/CT) | |||
| ||||||
IBD N (%) | 256 | 184.0 (71.9) | 37.3 (14.6) | 12.0 (4.7) | 19.0 (7.4) | |
OR (C.I.) | 1.3 (0.84–2.02) | 0.86 (0.49–1.5) | 0.51 (0.23–1.15) | 1.24 (0.55–2.81) | ||
UC N (%) | 126 | 89.0 (70.6) | 19.6 (15.6) | 6.0 (4.8) | 9.0 (7.1) | |
OR (C.I.) | 1.23 (0.73–2.05) | 0.93 (0.49–1.78) | 0.52 (0.19–1.41) | 1.19 (0.46–3.09) | ||
CD N (%) | 130 | 95.0 (73.1) | 17.6 (13.5) | 6.0 (4.6) | 10.0 (7.7) | |
OR (C.I.) | 1.39 (0.83–2.32) | 0.79 (0.41–1.54) | 0.5 (0.19–1.36) | 1.29 (0.51–3.27) | ||
Controls | 148 | 98.0 (66.2) | 24.5 (16.6) | 13.0 (8.8) | 9.0 (6.1) | |
| ||||||
D5 (CT/GT) | D6 (GC/GT) | D7 (GC/CT) | D8 (GT/GT) | P (c) | ||
| ||||||
IBD N(%) | 2.0 (0.8) | 0.0 (0) | 0.7 (0.3) | 1.0 (0.4) | 0.409 | |
OR (C.I.) | 0.58 (0.08–4.12) | — | — | — | ||
UC N (%) | 1.0 (0.8) | 0.0 (0) | 0.0 (0) | 1.0 (0.8) | 0.716 | |
OR (C.I.) | — | — | — | |||
CD N (%) | 0.0 (0) | 0.0 (0) | 0.0 (0) | 0.0 (0) | 0.588 | |
OR (C.I.) | — | — | — | |||
Controls | 2.0 (1.4) | 1.0 (0.7) | 0.5 (0.3) (d) | 0.0 (0) |
OR: odds ratio; CI: confidence interval; N: absolute number; H1–H4: haplotype 1—haplotype 4; D1–D8: diplotype 1—diplotype 8; (a)the first base denotes the outcome at position rs1801282, the second base denotes the outcome at position rs1801282; (b)each base pair (before and after the slash) denotes one haplotype; (c) P values calculated with FAMHAP; (d)frequency predicted to be 0.0 when comparing UC patients with controls.