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PR-Set7 is highly regulated during, and is important for multiple aspects of, the cell cycle. PR-Set7 levels oscillate—as shown by YFP-PR-Set7 (green) expression in the outer circle—during the different stages of the cell cycle (mCherry-PCNA). PR-Set7 is post-translationally regulated by multiple different enzymes during the cell cycle, including CRL4-Cdt2, SCF-Skp2, APC-Cdh1, and Cyclin B1/Cdk1. The various functions of PR-Set7 and H4K20me1 are listed within the cell cycle circle.
