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. 2012 Feb 15;26(4):325–337. doi: 10.1101/gad.177444.111

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Copyright © 2012 by Cold Spring Harbor Laboratory Press

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Figure 3. — Role of PR-Set7 in genome integrity. PR-Set7 has multiple functions that are important for proper genome stability and DNA damage response. (Top left) PR-Set7 methylates H4K20me1, which is important for recruiting 53BP1 recruitment to sites of DNA damage. (Top right) PR-Set7 alters p53-dependent gene expression, potentially regulating checkpoint and repair processes. (Bottom left) H4K20me alters chromatin compaction and mitotic condensation, thereby affecting higher-order chromatin structure. Finally, PR-Set7 and H4K20me are required for proper DNA replication, possibly through regulation of fork stability.