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. 2012 Feb 15;26(4):384–394. doi: 10.1101/gad.175802.111

Figure 1.

Figure 1.

Sequence profiles of the mtDNA mutations in LA9 and LMTK cells. AF show six heteroplasmic mtDNA polypeptide mutations. These include ND2 C4794T (A), COI T6589C (B), ND5 T12048C (C), ND6 13885insC (D), [tRNAArg 9821(9A)] versus [tRNAArg 9821(10A)] (E), and ND5 13053insC (F) found in LA9W1998 and/or LA9W2002. In E, the tRNAArg 9821 locus 9As is a wild-type allele and 10As is a mutant. This locus is heteroplasmic in LA9W1998, homoplasmic wild type in LA9W2002 (top; 9As), and homoplasmic mutant in LMTK (bottom; 10As). With the exception of tRNAArg 9821, the top trace is mutant, and the bottom is wild type. The wild-type genotype for C3H and 129 mice is [ND2 4794C]-[COI 6589T]-[tRNAArg 9821(9A)]-[ND5 12048T]-[ND5 13050(7C)]-[ND6 13885insC].

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